Research Assistant I
Department Description: Dr. Steven Balk’s laboratory conducts basic and translational research in cancer biology, with a focus on prostate cancer and the proteins and pathways that are critical for tumor development and progression. A major effort has been to understand the role of the androgen receptor (AR), a steroid hormone receptor that is highly expressed and critical for the growth of most prostate cancers. Dr. Balk and his colleagues have identified several mechanisms by which prostate cancer cells escape standard androgen-deprivation therapies and progress to lethal castration-resistant prostate cancers. One of their long-term objectives is to develop new therapies that more effectively target AR prevent the emergence of castration resistance.
Dr. Balk’s lab is also pursuing additional approaches to treat prostate cancer, including therapies that target certain kinases and apoptotic pathways, WNT pathway signaling, and immunotherapy. For men with early stage prostate cancer, the lab is studying molecular features that may distinguish men with indolent prostate cancer who can be observed versus those who need treatment, and is studying neoadjuvant and adjuvant therapies for the latter group. Finally, the lab is developing patient derived xenograft and organoid models of prostate cancer for further study.
Job Location: Boston, MA
Req ID: 38772BR
Job Summary: The Research Assistant will assist with basic and translational research studies in cancer biology. Experience with basic molecular and cellular biology laboratory methods, including cell culture, immunoblotting, PCR, is a requirement, and a commitment of at least two years is preferred.
Department Specific Job Responsibilities:
- Maintains and organizes zebrafish and mouse wild type and mutant strains. Participates in feeding, genotyping, and performing procedures on animals.
- Keeps meticulous laboratory notebook documenting all experiments.
- Conducts routine tests following established procedures, which may include assays, DNA sequencing, tissue culture, protein purification, Southern blotting, PCR analysis, electrophoresis, chromatography, etc.
- Uses standard research equipment such as microscopes, incubators, autoclaves, centrifuges, etc.
- Researches and collects basic study data through monitoring devices and maintains daily logs/basic records of methodologies and test results. With supervision, using databases, may summarize data and interpret results using descriptive statistics and basic hypothesis testing.
- May write standard operating procedures for documentation and make informal presentations of these procedures to others in the lab.
- Performs literature searches and library investigations as they relate to the research and/or as assigned.
- Bachelor's degree in Biology, Biochemistry, Life Science or a related scientific field required. required. Bachelor's degree in Biology or related field preferred.
- 0-1 years related work experience required.
- Familiarity with basic laboratory instruments and equipment, computers (databases, spreadsheets, statistics) and scientific procedures.
- Basic familiarity with computers. Ability to navigate at a basic level within web-based applications.
- Ability to work in a fast paced environment, to juggle and prioritize multiple competing tasks and demands, and to seek supervisory assistance as appropriate.
- Highly motivated with strong communication skills and ability to collaborate with other members of the laboratory team.
- Decision Making: Ability to make decisions that are based on specific instructions, standard practices and established procedures which generally require little or no supervision.
- Problem Solving: Ability to address problems that are routine, somewhat repetitive and generally solved by following clear directions and procedures and by identifying opportunities for process improvements.
- Independence of Action: Ability to follow general instructions and procedures as provided. Work is monitored by supervisor/manager.
- Written Communications: Ability to read, and write in English in order to understand basic safety instructions and take direction from supervisors; communicate effectively with patients, families and other medical center staff; and respond to basic questions.
- Oral Communications: Ability to understand spoken English in order to follow basic safety instructions and take direction from supervisors; communicate effectively in basic English with patients, families and medical center staff in response to routine questions.
- Knowledge: Ability to demonstrate basic knowledge of fundamental concepts, practices and procedures with the ability to use them in routine situations. Specialized knowledge not required.
- Team Work: Ability to interact respectfully with other employees, professional staff and/or external contacts to offer ideas, identify issues, obtain information or deliver services.
- Customer Service: Ability to demonstrate a positive attitude and respond to requests in a timely and respectful manner.
Physical Nature of the Job:
Light work: Exerting up to 20 pounds of force frequently to move objects. Some elements of the job are sedentary, but the employee will be required to stand for periods of time or move through out the hospital campus